The XCZU49DR-2FFVF1760I RFSoC is widely deployed in phased-array radar, 5G radio units, satellite communications, software-defined radio (SDR), and high-speed test and measurement systems. When multiple ADC and DAC channels operate simultaneously, engineers may encounter data misalignment, phase inconsistencies, random data loss, or channel no-output issues. In most cases, these problems are not caused by hardware failure but by synchronization misconfiguration, clock quality issues, JESD204B parameter mismatches, power integrity deficiencies, or PCB signal integrity problems. This article provides a streamlined troubleshooting methodology and practical solutions to rapidly identify and resolve multi-channel RFSoC issues.